Prelimbic prefrontal cortex mediates respiratory responses to mild and potent prolonged, but not brief, stressors

• Published in: Respiratory physiology & neurobiology Vol. 204; pp. 21 - 27
• Main Authors: Bondarenko, E, Hodgson, D.M, Nalivaiko, E
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-12-2014
• Subjects: Acoustic Stimulation - methods; Animals; Arousal; Catheters, Indwelling; Disease Models, Animal; GABA-A Receptor Agonists - pharmacology; Male; Medial prefrontal cortex; Medical Education; Microinjections; Muscimol - pharmacology; Photic Stimulation - methods; Plethysmography; Prefrontal Cortex - drug effects; Prefrontal Cortex - physiopathology; Prelimbic prefrontal cortex; Pulmonary/Respiratory; Rats, Wistar; Receptors, GABA-A - metabolism; Respiration - drug effects; Respiratory rate; Restraint, Physical; Stress; Stress, Psychological - drug therapy; Stress, Psychological - physiopathology; Tachypnea - drug therapy; Tachypnea - physiopathology; Tidal volume; Time Factors; Medial prefrontal cortex; Respiratory rate; Stress; Tidal volume; Arousal; Prelimbic prefrontal cortex
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2014.07.009

Highlights • We assessed respiration in rats with and without prelimbic PFC (plPFC) inactivation. • We presented arousing and stressful stimuli of varying intensities and lengths. • Blockade of the plPFC attenuated respiratory responses only to prolonged stressors. • Blockade of the plPFC did not affect respiratory responses to brief stressors.