Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Thiosulfate in Human Blood and Urine as an Indicator of Hydrogen Sulfide Poisoning

Highlights • Quantitative determination method for thiosulfate by LC-MS/MS was developed. • Thiosulfate can be utilized for an index of hydrogen sulfide poisoning. • The established method is more rapid and simple comparing to GC/MS method. • The method could estimate thiosulfate concentrations in 1...

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Bibliographic Details
Published in:	Legal medicine (Tokyo, Japan) Vol. 24; pp. 67 - 74
Main Authors:	Maseda, Chikatoshi, Hayakawa, Akira, Okuda, Katsuhiro, Asari, Masaru, Tanaka, Hiroki, Yamada, Hiromi, Jin, Shigeki, Horioka, Kie, Matoba, Kotaro, Shiono, Hiroshi, Matsubara, Kazuo, Shimizu, Keiko
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-01-2017
Subjects:	Chromatography, Liquid - methods Forensic Toxicology Humans Hydrogen sulfide Hydrogen Sulfide - poisoning Internal Medicine LC-MS/MS Qualitative Research Quantitative determination Tandem Mass Spectrometry - methods Thiosulfate Thiosulfates - blood Thiosulfates - urine Hydrogen sulfide LC-MS/MS Thiosulfate Quantitative determination
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Summary:	Highlights • Quantitative determination method for thiosulfate by LC-MS/MS was developed. • Thiosulfate can be utilized for an index of hydrogen sulfide poisoning. • The established method is more rapid and simple comparing to GC/MS method. • The method could estimate thiosulfate concentrations in 12 forensic autopsy cases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1344-6223 1873-4162
DOI:	10.1016/j.legalmed.2016.12.004