Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines

• Published in: Bioorganic & medicinal chemistry Vol. 16; no. 21; pp. 9546 - 9553
• Main Authors: Andrianina Ralambomanana, Dimby, Razafimahefa-Ramilison, Dorothée, Rakotohova, Andry Clément, Maugein, Jeanne, Pélinski, Lydie
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01-11-2008; Elsevier
• Series: Bioorganic and Medicinal Chemistry Letters
• Subjects: Amino Alcohols - chemical synthesis; Amino Alcohols - chemistry; Amino Alcohols - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antitubercular Agents - chemical synthesis; Antitubercular Agents - pharmacology; Biological and medical sciences; Chemical Sciences; Diamine; Diamines - chemical synthesis; Diamines - chemistry; Diamines - pharmacology; Ethambutol; Ferrocene; Ferrous Compounds - chemical synthesis; Ferrous Compounds - pharmacology; Medical sciences; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Mycobacterium tuberculosis - drug effects; Pharmacology. Drug treatments; Structure-Activity Relationship; Diamine; Ethambutol; Mycobacterium tuberculosis; Ferrocene; Aminoalcohol; In vitro; Metallocene; Biological activity; Iron Organic compounds; Mycobacteriales; Mycobacteriaceae; Bacteria; Actinomycetes; Antituberculous agent; Antibacterial agent; Chemical synthesis
• ISSN: 0968-0896; 0960-894X; 1464-3391
• DOI: 10.1016/j.bmc.2008.09.030

Ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against
Mycobacterium tuberculosis H37Rv.
A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against
Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exhibit better activities than ferrocenyl diaminoalcohols.