Sandramycin, a novel antitumor antibiotic produced by a Nocardioides sp. Production, isolation, characterization and biological properties

A new antitumor antibiotic, sandramycin, was isolated from cultured broth of a Nocardioides sp. (ATCC 39419) and purified by solvent partition and column chromatography. Sandramycin, a new depsipeptide, was moderately active in vitro against Gram-positive organisms and in vivo against leukemia P388...

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Bibliographic Details
Published in:	Journal of antibiotics Vol. 42; no. 12; p. 1763
Main Authors:	Matson, J A, Bush, J A
Format:	Journal Article
Language:	English
Published:	Japan 1989
Subjects:	Animals Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - therapeutic use Chemical Phenomena Chemistry Gram-Positive Bacteria - drug effects Leukemia P388 - drug therapy Mice Microbial Sensitivity Tests Nocardiaceae - analysis Peptides, Cyclic - isolation & purification Peptides, Cyclic - therapeutic use Quinolines - isolation & purification Quinolines - therapeutic use
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Summary:	A new antitumor antibiotic, sandramycin, was isolated from cultured broth of a Nocardioides sp. (ATCC 39419) and purified by solvent partition and column chromatography. Sandramycin, a new depsipeptide, was moderately active in vitro against Gram-positive organisms and in vivo against leukemia P388 in mice.
ISSN:	0021-8820
DOI:	10.7164/antibiotics.42.1763