Cancer stem cell markers in common cancers – therapeutic implications

Rapid advances in the cancer stem cell (CSC) field have provided cause for optimism for the development of more reliable cancer therapies in the future. Strategies aimed at efficient targeting of CSCs are becoming important for monitoring the progress of cancer therapy and for evaluating new therape...

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Bibliographic Details
Published in:	Trends in molecular medicine Vol. 14; no. 10; pp. 450 - 460
Main Authors:	Klonisch, Thomas, Wiechec, Emilia, Hombach-Klonisch, Sabine, Ande, Sudharsana R, Wesselborg, Sebastian, Schulze-Osthoff, Klaus, Los, Marek
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-2008
Subjects:	Biomarkers, Tumor - metabolism Humans Models, Biological Neoplasms - metabolism Neoplasms - therapy Neoplastic Stem Cells - metabolism Pathology
Online Access:	Get full text
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Summary:	Rapid advances in the cancer stem cell (CSC) field have provided cause for optimism for the development of more reliable cancer therapies in the future. Strategies aimed at efficient targeting of CSCs are becoming important for monitoring the progress of cancer therapy and for evaluating new therapeutic approaches. Here, we characterize and compare the specific markers that have been found to be present on stem cells, cancer cells and CSCs in selected tissues (colon, breast, liver, pancreas and prostate). We then discuss future directions of this intriguing new research field in the context of new diagnostic and therapeutic opportunities.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1471-4914 1471-499X 1471-499X
DOI:	10.1016/j.molmed.2008.08.003