The Role of the Nuclear Factor-Kappa B (NF-κB) Pathway in SARS-CoV-2 Infection

• Published in: Pathogens (Basel) Vol. 13; no. 2; p. 164
• Main Authors: Kesika, Periyanaina, Thangaleela, Subramanian, Sisubalan, Natarajan, Radha, Arumugam, Sivamaruthi, Bhagavathi Sundaram, Chaiyasut, Chaiyavat
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-02-2024; MDPI
• Subjects: Chemokines; Coronaviruses; COVID-19; Cytokine storm; cytokines; Disease transmission; Epidemics; Failure; Fatalities; Global health; Health aspects; Health risks; Immune system; Infections; Inflammation; Lungs; Middle East respiratory syndrome; Morbidity; Mutation; NF-κB; NF-κB protein; Pathogenesis; Physiological aspects; Pneumonia; Proteins; Public health; Respiratory diseases; Respiratory failure; Review; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Transcription factors; Tumor necrosis factor-TNF; Viral diseases; Viral infections; Viruses; Zoonoses; Thailand; COVID-19; NF-κB; SARS-CoV-2; cytokines; inflammation
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens13020164

COVID-19 is a global health threat caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with a significant increase in morbidity and mortality. The present review discusses nuclear factor-kappa B (NF-κB) activation and its potential therapeutical role in treating COVID-19. COVID-19 pathogenesis, the major NF-κB pathways, and the involvement of NF-κB in SARS-CoV-2 have been detailed. Specifically, NF-κB activation and its impact on managing COVID-19 has been discussed. As a central player in the immune and inflammatory responses, modulating NF-κB activation could offer a strategic avenue for managing SARS-CoV-2 infection. Understanding the NF-κB pathway's role could aid in developing treatments against SARS-CoV-2. Further investigations into the intricacies of NF-κB activation are required to reveal effective therapeutic strategies for managing and combating the SARS-CoV-2 infection and COVID-19.