Signaling Pathways and Potential Therapeutic Strategies in Cardiac Fibrosis

• Published in: International journal of molecular sciences Vol. 24; no. 2; p. 1756
• Main Authors: Bertaud, Alexandrine, Joshkon, Ahmad, Heim, Xavier, Bachelier, Richard, Bardin, Nathalie, Leroyer, Aurélie S, Blot-Chabaud, Marcel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16-01-2023; MDPI
• Subjects: Aging; biomarker; Bone marrow; cardiac fibrosis; Cardiac function; Cardiac muscle; Cardiomyopathies - metabolism; Chronic illnesses; Collagen; Diabetes; Diabetes mellitus; Disease; Exosomes; Extracellular matrix; fibroblast; Fibroblasts; Fibrosis; Growth factors; Heart; heart failure; Humans; Hypertension; Life Sciences; Mortality; Muscles; Myocardial infarction; Myocardial Infarction - metabolism; Myocardium - metabolism; Nanoparticles; Necrosis; Phosphorylation; Prenatal development; Proteins; Review; Signal Transduction; signaling pathways; Smooth muscle; therapy; heart failure; fibroblast; signaling pathways; biomarker; cardiac fibrosis; therapy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms24021756

Cardiac fibrosis constitutes irreversible necrosis of the heart muscle as a consequence of different acute (myocardial infarction) or chronic (diabetes, hypertension, …) diseases but also due to genetic alterations or aging. Currently, there is no curative treatment that is able to prevent or attenuate this phenomenon that leads to progressive cardiac dysfunction and life-threatening outcomes. This review summarizes the different targets identified and the new strategies proposed to fight cardiac fibrosis. Future directions, including the use of exosomes or nanoparticles, will also be discussed.