Central nervous system involvement in n-hexane polyneuropathy demonstrated by MRI and proton MR spectroscopy

• Published in: Clinical neurology and neurosurgery Vol. 113; no. 6; pp. 493 - 495
• Main Authors: Hashizume, A, Koike, H, Kawagashira, Y, Banno, H, Suzuki, K, Ito, M, Katsuno, M, Watanabe, H, Tanaka, F, Naganawa, S, Kaneko, R, Ishii, A, Sobue, G
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01-07-2011; Elsevier; Elsevier Limited
• Subjects: Biological and medical sciences; Biopsy; Brain; Brain - pathology; Central nervous system; Central Nervous System Diseases - chemically induced; Central Nervous System Diseases - etiology; Central Nervous System Diseases - pathology; Female; Gas Chromatography-Mass Spectrometry; Hexanes - poisoning; Humans; Inhalant Abuse - complications; Inhalant Abuse - pathology; Lactate peak; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical sciences; Middle Aged; n-Hexane; Nervous system; Neurologic Examination; Neurology; Neurosurgery; Neurotoxicity Syndromes - complications; Neurotoxicity Syndromes - pathology; Polyneuropathies - chemically induced; Polyneuropathies - complications; Polyneuropathies - pathology; Polyneuropathy; Spinal cord; Sural Nerve - pathology; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Magnetic resonance spectroscopy; Lactate peak; n-Hexane; Polyneuropathy; Central nervous system; Nervous system diseases; NMR spectrometry; Nuclear magnetic resonance imaging; Lactates; Surgery; Proton; Hexane; Peripheral nerve disease; Lactic acid
• ISSN: 0303-8467; 1872-6968
• DOI: 10.1016/j.clineuro.2011.01.008

In the present report, we describe a patient with n-hexane polyneuropathy with CNS lesions using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H MRS).2 Case report A 51-year-old woman complained of difficulty rising up from a seated position and climbing stairs for six months prior to admission to our hospital. In a brainstem auditory evoked potential (BAEP) study, absolute latencies of I, III, and V were 1.66ms, 4.16ms, and 6.36ms, respectively (normal values [mean±SD]: 1.7±0.15, 3.9±0.19, and 5.7±0.25, respectively). [...]the I-III, III-V, and I-V interpeak latencies were 2.50ms, 2.20ms, and 4.70ms, respectively (normal values: 2.1±0.15, 1.9±0.18, and 4.0±0.23, respectively). Oge et al. described a central nerve conduction delay using the electrophysiological method of transcranial magnetic stimulation [5]. [...]studies using patterned visual evoked potential (pVEP), brainstem auditory evoked potential (BAEP), and somatosensory evoked potential (SEP) have suggested subclinical central nerve involvement in n-hexane neuropathy [2].