Individual variability of olfactory fMRI in normosmia and olfactory dysfunction

• Published in: European archives of oto-rhino-laryngology Vol. 278; no. 2; pp. 379 - 387
• Main Authors: Yunpeng, Zang, Han, Pengfei, Joshi, Akshita, Hummel, Thomas
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2021
• Subjects: Adult; Brain; Head and Neck Surgery; Humans; Magnetic Resonance Imaging; Medicine; Medicine & Public Health; Middle Aged; Neurosurgery; Odorants; Olfaction Disorders - diagnostic imaging; Otorhinolaryngology; Rhinology; Smell; fMRI; Individual variability; Olfactory dysfunction; Objective diagnosis
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-020-06233-y

Purpose
The diagnosis of olfactory dysfunction is mainly based on psychophysical measurements. The aim of the current study was to investigate how well the olfactory functional magnetic resonance imaging (fMRI) can effectively distinguish between normosmic people and subjects with olfactory dysfunction.
Methods
Thirty-eight participants were recruited for the study. Group 1 consisted of 22 subjects with olfactory dysfunction (mean age = 44.3 years, SD = 18.6), and Group two consisted of 16 participants with normal olfactory function (mean age = 49.6 years, SD = 11.6). Olfactory functions were assessed in great detail for all participants, and brain activation in response to odorous stimulation was assessed using fMRI.
Results
The between-group comparison showed stronger odor induced brain activation of the primary olfactory area and the insular cortex among the normosmic group as compared to the dysosmic group. As indicated by the individual analysis, positive responses in the primary olfactory cortex were significantly higher in normosmic people (94%) than in subjects with olfactory dysfunction (41%). However, there was no association between individual fMRI parameters (including the percentage of BOLD signal change, activated cluster size and peak
z
value), and psychophysical olfactory test scores. Receiver operating characteristic analysis suggested the subjects could not be differentiated from normosmics based on their BOLD signal from the primary olfactory area, orbitofrontal cortex, or the insular cortex.
Conclusion
There are large inter-individual variabilities for odor-induced brain activation among normosmic subjects and subjects with olfactory dysfunction, due to this variation, at present it appears problematic to diagnose olfactory dysfunction on an individual level using fMRI.