Rosai–Dorfman Disease: A Rare Clinicopathological Presentation and Review of the Literature

Rosai–Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation o...

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Bibliographic Details
Published in:	Head & neck pathology (Totowa, N.J.) Vol. 15; no. 1; pp. 352 - 360
Main Authors:	Azari-Yaam, Aileen, Abdolsalehi, Mohammad Reza, Vasei, Mohammad, Safavi, Moeinadin, Mehdizadeh, Mehrzad
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-03-2021
Subjects:	Case Reports Dentistry Medicine Medicine & Public Health Oral and Maxillofacial Surgery Otorhinolaryngology Pathology Immunohistochemistry Lymphophagocytosis Sinonasal mass Emperipolesis Rosai–Dorfman disease Cervical lymphadenopathy Sinus histiocytosis with massive lymphadenopathy
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Summary:	Rosai–Dorfman disease (RDD) is a rare and self-limiting disease process that presents most commonly in young patients as massive, painless, cervical lymphadenopathy. Extranodal involvement may also occur. Histopathologic evaluation is the main diagnostic modality. We report an unusual presentation of RDD with cervical lymphadenopathy and an incidentally discovered sinonasal mass, clinically worrisome for malignancy. We emphasize that a high index of clinical suspicion is critical for accurate diagnosis of RDD. Clinicians and pathologists should consider RDD in a differential diagnosis of cervical lymphadenopathy, especially in young patients.
Bibliography:	ObjectType-Case Study-3 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Review-1 ObjectType-Feature-5 ObjectType-Report-2 ObjectType-Article-4
ISSN:	1936-0568 1936-055X 1936-0568
DOI:	10.1007/s12105-020-01183-7