Rare case of disseminated fusariosis in a young patient with graft vs. host disease following an allogeneic transplant

• Published in: Experimental and therapeutic medicine Vol. 12; no. 4; pp. 2078 - 2082
• Main Authors: Tanase, Alina, Colita, Anca, Ianosi, Gabriel, Neagoe, Daniela, Branisteanu, Daciana Elena, Calina, Daniela, Docea, Anca Oana, Tsatsakis, Aristidis, Ianosi, Simona Laura
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01-10-2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: allogeneic stem cell transplant; Bone marrow; Case studies; Disease prevention; Fungal infections; Fungi; fusariosis; Graft versus host disease; Graft versus host reaction; immunosuppression; Medical imaging; Mortality; Mycoses; Neutropenia; Patients; Rare diseases; Skin; Stem cell transplantation; Stem cells; Studies; Tomography; immunosuppression; allogeneic stem cell transplant; fusariosis
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2016.3562

Fusarium infection is a severe fungal infection caused by fungi of the genus Fusarium. It most commonly occurs in immunocompromised patients with malignant hematological comorbidities or secondary to hematopoietic stem cell transplant. The classical route of contamination is through inhalation but infection may also occur through contiguity with a skin lesion. This report describes the case of a 24-year-old woman who developed graft-vs.-host disease (GVHD) at 220 days after receiving an allogeneic stem cell transplant from a sibling donor for Hodgkin disease. On day 330 after transplant the patient presented with fever and several painful subcutaneous, tender, red nodules with ulcerative and necrotic features on the pelvic region and right leg, extensive glass infiltrative lesions in the lungs and pansinusitis; however, the patient did not have onychomycosis. Following skin biopsy, culture of cutaneous lesions, computed tomography (CT) scanning of the lungs and CT scanning and magnetic resonance imaging of facial sinuses the patient was diagnosed with disseminated Fusarium species infection. Despite intensive treatment with voriconazole, the patient succumbed with respiratory insufficiency on day 400 after transplant. This case is noteworthy because the patient did not have any additional risk associated with the allogeneic transplant; there was no transplant mismatch, no severe neutropenia and no prior clinical signs of onychomycosis. The association of skin lesions with GVHD lesions increased the initial immunosuppression and delayed diagnosis.