Neonatal lipopolysaccharide treatment alters hippocampal neuroinflammation, microglia morphology and anxiety-like behavior in rats selectively bred for an infantile trait

Highlights • Neonatal immune challenge increases anxiety-like behavior in a low-anxiety rat line. • Neonatal immune challenge reduces anxiety-like behavior in a high-anxiety rat line. • Neonatal immune challenge alters peripheral inflammation in a phenotypic-dependent manner. • Sex and phenotype int...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 59; pp. 135 - 146
Main Authors:	Claypoole, Lauren D, Zimmerberg, Betty, Williamson, Lauren L
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-01-2017
Subjects:	Allergy and Immunology Animals Animals, Newborn Anxiety Anxiety - psychology Behavior, Animal Cytokines - biosynthesis Development Female Hippocampus - pathology Immunity - drug effects Inflammation - pathology Lipopolysaccharides - pharmacology Male Microglia Microglia - pathology Motor Activity Neonatal inflammation Psychiatry Rats Sex Characteristics Vocalization, Animal Development Anxiety Neonatal inflammation Microglia
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Summary:	Highlights • Neonatal immune challenge increases anxiety-like behavior in a low-anxiety rat line. • Neonatal immune challenge reduces anxiety-like behavior in a high-anxiety rat line. • Neonatal immune challenge alters peripheral inflammation in a phenotypic-dependent manner. • Sex and phenotype interact after neonatal LPS to alter anxiety-like behavior.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.08.017