Correlations among vitamin K intake, body fat, lipid profile and glucose homeostasis in adults and the elderly
ABSTRACT Objective Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diab...
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| Published in: | Archives of Endocrinology and Metabolism Vol. 64; no. 4; pp. 436 - 444 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Endocrinologia e Metabologia
01-08-2020
Brazilian Society of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | ABSTRACT Objective Recent research has investigated the possible inverse relationship between vitamin K intake and body fat. In addition, an increasing number of studies are supporting a key role for this vitamin in improving lipid profile and insulin sensitivity and reducing the risk of type 2 diabetes mellitus, but little is known about what mechanisms would be involved. Thus, the objective of this study was to investigate the relationship between vitamin K intake (in the form of phylloquinone – PK), body fat, lipid profile and markers of glucose homeostasis in adults and the elderly. Subjects and methods A cross-sectional study with 298 participants (46% men) in the São Paulo Health Survey 2014-2015. Spearman correlations were performed to evaluate the associations between vitamin K intake and the biochemical and body composition measures. Results Among normal-weight male adults (n = 15), PK intake presented a positive correlation with the quantitative insulin sensitivity check index (QUICKI) (r = 0.525; p = 0.045). Among men with high fat mass index (FMI) (n = 101), PK intake had a negative correlation with homeostasis model assessment estimate for β-cell function (HOMA-β) (r = −0.227; p = 0.022). In women with high FMI (n = 122), PK intake had a negative correlation with HOMA-β (r = −0.199, p = 0.032) and insulin (r = −0.207, p = 0.026). No correlations were found between PK intake and lipid profile. Conclusions Our findings support a potential relationship among PK intake, body fat and markers of glucose homeostasis in adults and the elderly. |
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| Bibliography: | Disclosure: no potential conflict of interest relevant to this article was reported. Individual contributions: Elizabete A. Santos performed the literature review, assisted with the data collection, performed statistical analyses and wrote the manuscript. Kelly V. Giudici and Lígia A. Martini designed the protocol, assisted with the statistical analyses and interpreted data and were responsible for reviewing and correcting all of the article’s content. Natasha A.G. de França participated in the data collection, performed the dual-energy X-ray absorptiometry (DXA) and assisted in the statistical analysis. Barbara S. Emo Peters critically revised the manuscript and also assisted in the statistical analysis. Regina Mara Fisberg was responsible for the data collection procedures related to the São Paulo Health Survey (ISA-Capital 2015) and critically revised the manuscript. All of the authors critically reviewed the manuscript and approved the final version submitted for publication. Transparency declaration: the lead author affirms that this manuscript is an honest, accurate and transparent account of the study being reported. The reporting of this work is compliant with STROBE guidelines. The lead author affirms that no important aspects of the study have been omitted and that any discrepancies from the study as planned have been explained. |
| ISSN: | 2359-3997 2359-4292 |
| DOI: | 10.20945/2359-3997000000230 |