Antihyperglycemic effect of methanol extract of Tamarix aphylla L. Karst (Saltcedar) in streptozocin–nicotinamide induced diabetic rats

• Published in: Asian Pacific journal of tropical biomedicine Vol. 7; no. 7; pp. 619 - 623
• Main Authors: Ullah, Rooh, Tariq, Shafiq Ahmed, Khan, Naeem, Sharif, Nawaz, Ud Din, Zia, Mansoor, Khalid
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-07-2017; Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, KPK, Pakistan; Wolters Kluwer Medknow Publications
• Subjects: Antidiabetic potential; Diabetes; Insulin secretion; Streptozotocin; Tamarix aphylla leaves; Tamarix aphylla leaves; Diabetes; Streptozotocin; Antidiabetic potential; Insulin secretion
• ISSN: 2221-1691; 2588-9222
• DOI: 10.1016/j.apjtb.2017.06.005

Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla (T. aphylla) leaves in STZ–NIC induced diabetes in Wister Albino rats. Methods: Acute toxicity study was done to check the toxicity of T. aphylla (L. Karst) methanol extract. T. aphylla leaves extract was administered intraperitoneally (100 mg, 250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated haemoglobin. Results: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of extract. Conclusions: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature.