Influence of the Gut Microbiota on the Development of Neurodegenerative Diseases

• Published in: Mediators of inflammation Vol. 2022; pp. 3300903 - 12
• Main Authors: Singh, Mahendra P., Chakrabarty, Riya, Shabir, Shabnam, Yousuf, Sumaira, Obaid, Ahmad A., Moustafa, Mahmoud, Al-Shehri, Mohammed, Al-Emam, Ahmed, Alamri, Abdulhakeem S., Alsanie, Walaa F., Alhomrani, Majid, Shkodina, Anastasiia D., Singh, Sandeep K.
• Format: Journal Article
• Language: English
• Published: United States Hindawi 30-09-2022; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Alzheimer's disease; Amyotrophic lateral sclerosis; Bacteria; Brain; Brain-derived neurotrophic factor; Clinical trials; Cognitive ability; Degeneration; Dementia; Digestive system; Etiology; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Genomes; Humans; Inflammation; Intestinal microflora; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Mitochondria; Mutation; Nervous system; Neurodegeneration; Neurodegenerative Diseases; Neurological diseases; Neurons; Older people; Parkinson's disease; Physiology; Protein folding; Proteins; Review; Saudi Arabia
• ISSN: 0962-9351; 1466-1861; 1466-1861
• DOI: 10.1155/2022/3300903

Neurodegenerative disorders are marked by neuronal death over time, causing a variety of cognitive and motor dysfunctions. Protein misfolding, neuroinflammation, and mitochondrial and protein clearance system dysfunction have all been identified as common pathways leading to neurodegeneration in recent decades. An altered microbiome of the gut, which is considered to play a central role in diseases as well as health, has recently been identified as another potential feature seen in neurodegenerative disorders. An array of microbial molecules that are released in the digestive tract may mediate gut-brain connections and permeate many organ systems, including the nervous system. Furthermore, recent findings from clinical as well as preclinical trials suggest that the microbiota of the gut plays a critical part in gut-brain interplay and that a misbalance in the composition of the gut microbiome may be linked to the etiology of neurological disorders (majorly neurodegenerative health problems); the underlying mechanism of which is still unknown. The review aims to consider the association between the microbiota of the gut and neurodegenerative disorders, as well as to add to our understanding of the significance of the gut microbiome in neurodegeneration and the mechanisms that underlie it. Knowing the mechanisms behind the gut microbiome’s role and abundance will provide us with new insights that could lead to novel therapeutic strategies.