Patterns of donor-type microchimerism after heart transplantation

Allogeneic microchimerism of donor-type has been demonstrated in stable patients in the long-term after organ transplantation. We have analysed microchimerism in skin and blood of 47 heart-transplanted patients after transplantation with polymerase-chain-reaction amplification specific for donor HLA...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 343; no. 8911; p. 1469
Main Authors:	Schlitt, H J, Hundrieser, J, Hisanaga, M, Uthoff, K, Karck, M, Wahlers, T, Wonigeit, K, Pichlmayr, R
Format:	Journal Article
Language:	English
Published:	England 11-06-1994
Subjects:	Gene Amplification Heart Transplantation - immunology HLA-DR1 Antigen - analysis Humans Immune Tolerance - genetics Polymerase Chain Reaction Transplantation Chimera - genetics
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Summary:	Allogeneic microchimerism of donor-type has been demonstrated in stable patients in the long-term after organ transplantation. We have analysed microchimerism in skin and blood of 47 heart-transplanted patients after transplantation with polymerase-chain-reaction amplification specific for donor HLA-DRB1. Microchimerism was detectable in 50% of the patients in the first 6 months, in 100% between 6 months and 2 years, and in 58% in the third postoperative year or later. The state of chimerism was not related to acute or chronic rejections. Patterns of microchimerism after heart transplantation may be dynamic, but any association with clinical and immunological variables remains to be elucidated.
ISSN:	0140-6736
DOI:	10.1016/s0140-6736(94)92584-4