Th1- and Th2-cell commitment during infectious disease: asymmetry in divergent pathways

The development of T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to an infectious pathogen will lead to protection of the host or dissemination of the disease. Recent studies have suggested that this process i...

Full description

Saved in:

Bibliographic Details
Published in:	Trends in Immunology Vol. 22; no. 8; pp. 450 - 457
Main Authors:	Jankovic, Dragana, Liu, Zhugong, Gause, William C.
Format:	Book Review Journal Article
Language:	English
Published:	England Elsevier Ltd 01-08-2001
Subjects:	Animals CD4 T cell Chemokines - metabolism Communicable Diseases - immunology costimulation Cytokines - metabolism Dendritic Cells - immunology Humans infection Models, Biological Signal Transduction Th1 Th1 Cells - immunology Th2 Th2 Cells - immunology Transcription Factors - metabolism infection Parasitology Immunology costimulation CD4 T cell Cell biology Th1 Th2
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The development of T helper 1 (Th1) versus Th2 cells is a major branch point in the immune response. It is an important determinant of whether the response to an infectious pathogen will lead to protection of the host or dissemination of the disease. Recent studies have suggested that this process is governed by distinct sets of signals provided by dendritic cells upon interactions with specific infectious agents. A model is proposed that links together the pathogen, the innate response and Th-cell polarization.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1
ISSN:	1471-4906 1471-4981
DOI:	10.1016/S1471-4906(01)01975-5