Protective role of Anacardium occidentale extract against streptozotocin-induced diabetes in rats

• Published in: Journal of ethnopharmacology Vol. 62; no. 2; pp. 95 - 99
• Main Authors: Kamtchouing, Pierre, Sokeng, Selestin D, Moundipa, Paul F, Watcho, Pierre, Jatsa, Hermine B, Lontsi, David
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-09-1998; Elsevier
• Subjects: Anacardium occidentale; Animals; Biological and medical sciences; Blood Glucose - analysis; Diabetes mellitus; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - prevention & control; experimental diabetes; General pharmacology; Male; Medical sciences; medicinal plants; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Plants, Medicinal - chemistry; Rats; Rats, Wistar; Streptozocin; Streptozotocin; traditional medicine; Cameroon; Africa; Rats; Anacardium occidentale; Streptozotocin; Diabetes mellitus; Endocrinopathy; Rat; Pharmacognosy; Rodentia; Oral administration; Extract; Medicinal plant; Prevention; Vertebrata; Mammalia; Folk medicine; Dicotyledones; Animal; Angiospermae; Plant origin; Spermatophyta; Phytotherapy; Anacardiaceae
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(97)00159-1

The protective effect of
Anacardium occidentale aqueous extract against streptozotocin-induced diabetes was evaluated in rats. The rats were treated with 175 mg/kg of the extract per os, twice daily; beginning 2 days before streptozotocin (STZ) injection. A total of 3 days after STZ administration, there was a 48% increase in blood glucose level in pretreated rats, compared with a 208% increase in diabetic control rats treated with STZ alone. Furthermore, these pretreated animals presented no glycosuria, a normal weight gain and a non significant increase in food and fluid intake at the end of the treatment compared with the normal control. Diabetic control animals showed a positive glycosuria, body weight loss, a real polyphagia and polydypsia. These results indicate the protective role of
Anacardium occidentale extract against the diabetogenic action of STZ.