Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis

• Published in: Food science & nutrition Vol. 9; no. 8; pp. 4364 - 4374
• Main Authors: Hossain, Mohammad Shahadat, Barua, Anik, Tanim, Mohammad Akramul Hoque, Hasan, Mohammad Sharif, Islam, Mohammad Jahedul, Hossain, Md. Rabiul, Emon, Nazim Uddin, Hossen, S M Moazzem
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-08-2021; John Wiley and Sons Inc
• Subjects: Affinity; Alloxan; Animals; Antidiabetics; Atherosclerosis; Biological computing; Cholesterol; Computer applications; Degeneration; Diabetes; Diabetes mellitus; Docking; Drug dosages; Enzymes; Ganoderma applanatum; Glucose; Hepatitis; hepatoprotective; Herbal medicine; Hyperglycemia; Hyperlipidemia; hypolipidemic; Laboratories; Lipids; Liver; Liver diseases; Markers; Metabolism; Metabolites; mushroom; Mushrooms; Original Research; Pharmaceutical industry; Pharmacy; Bangladesh; hypolipidemic; diabetes mellitus; Ganoderma applanatum; mushroom; hepatoprotective
• ISSN: 2048-7177; 2048-7177
• DOI: 10.1002/fsn3.2407

This study was undertaken to evaluate the antidiabetic, hypolipidemic, and hepatoprotective effects of methanol and aqueous extracts of Ganoderma applanatum (MEGA, AEGA) in alloxan‐induced diabetic rats. The antidiabetic study was implemented by the induction of alloxan to the rats. The analysis of the hypolipidemic and liver‐protective effects of fungus extracts was studied by estimating the lipid profile and the liver marker enzymes. Besides, in silico screening of the compounds of Ganoderma applanatum has been incorporated thus to check the binding affinity of compounds and enzymes affinity. The Discovery Studio 2020, UCSF Chimera, and PyRx AutoDock Vina have been used to implement the docking analysis. Nine days of oral feeding of MEGA and AEGA of Ganoderma applanatum resulted in a significant (p < .001) reduction in blood glucose, lipid profile, and liver marker enzymes. Besides, Myrocin C scored the highest score in the docking study. The biological and computational approaches suggested the MEGA and AEGA could be a potential source for antidiabetic, hypolipidemic, and hepatoprotective effects.
This study aggregates, consolidates, and validates the use of mushroom for the treatment of diabetes, hyperlipidemia, and hepatic degenerations, Besides, the bioactive compounds have been accelerated to investigate the binding reactions with diabetes, hyperlipidemia, and hepatic receptors.