Perioperative neurocognitive disorders: A narrative review focusing on diagnosis, prevention, and treatment

• Published in: CNS neuroscience & therapeutics Vol. 28; no. 8; pp. 1147 - 1167
• Main Authors: Kong, Hao, Xu, Long‐Ming, Wang, Dong‐Xin
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01-08-2022; John Wiley and Sons Inc
• Subjects: Acetaminophen; Anesthesia; Anticholinergics; Benzodiazepines; Bone surgery; Cerebrovascular disease; Cognition; Cognitive ability; Comorbidity; Delirium; Dementia; Diabetes; Drug therapy; Etiology; Heart failure; Hypertension; Hypothermia; Inflammation; Intensive care; Mental disorders; Mortality; Narcotics; neurocognitive disorders; Nutritional status; Orthopedics; perioperative period; postoperative cognitive complications; Postoperative period; Quality of life; Recovery (Medical); Review; Risk factors; Surgery; Vitamin deficiency; neurocognitive disorders; perioperative period; postoperative cognitive complications; delirium
• ISSN: 1755-5930; 1755-5949
• DOI: 10.1111/cns.13873

Perioperative neurocognitive disorders (NCDs) refer to neurocognitive abnormalities detected during the perioperative periods, including preexisting cognitive impairment, preoperative delirium, delirium occurring up to 7 days after surgery, delayed neurocognitive recovery, and postoperative NCD. The Diagnostic and Statistical Manual of Mental Disorders‐5th edition (DSM‐5) is the golden standard for diagnosing perioperative NCDs. Given the impracticality of using the DSM‐5 by non‐psychiatric practitioners, many diagnostic tools have been developed and validated for different clinical scenarios. The etiology of perioperative NCDs is multifactorial and includes predisposing and precipitating factors. Identifying these risk factors is conducive to preoperative risk stratification and perioperative risk reduction. Prevention for perioperative NCDs should include avoiding possible contributors and implementing nonpharmacologic and pharmacological interventions. The former generally includes avoiding benzodiazepines, anticholinergics, prolonged liquid fasting, deep anesthesia, cerebral oxygen desaturation, and intraoperative hypothermia. Nonpharmacologic measures include preoperative cognitive prehabilitation, comprehensive geriatric assessment, implementing fast‐track surgery, combined use of regional block, and sleep promotion. Pharmacological measures including dexmedetomidine, nonsteroidal anti‐inflammatory drugs, and acetaminophen are found to have beneficial effects. Nonpharmacological treatments are the first‐line measures for established perioperative NCDs. Pharmacological treatments are still limited to severely agitated or distressed patients.
Perioperative neurocognitive disorders constitute a great challenge for older patients scheduled for surgery because their occurrence is associated with increased morbidity and mortality as well as enormous medical costs. Preoperative risk stratification and perioperative risk reduction should be adopted for perioperative NCDs prevention and treatment.