Mechanochemical Properties of Individual Human Telomeric RNA (TERRA) G-Quadruplexes

Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G‐quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacitie...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 14; no. 15; pp. 1931 - 1935
Main Authors:	Yangyuoru, Philip M., Zhang, Amy Y. Q., Shi, Zhe, Koirala, Deepak, Balasubramanian, Shankar, Mao, Hanbin
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 11-10-2013 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Subjects:	Base Sequence G-Quadruplexes Humans laser tweezers Mechanical Phenomena mechanical stability mechanochemistry Models, Molecular RNA - chemistry RNA - genetics RNA structures single molecules Telomere - genetics TERRA TERRA mechanochemistry G-quadruplexes laser tweezers mechanical stability RNA structures single molecules
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Summary:	Potential functions: By following the unfolding and refolding of individual human RNA telomeric (TERRA) G‐quadruplexes (GQs) in laser tweezers, the mechanical stability and transition kinetics of RNA GQs are obtained. Comparison between TERRA and DNA GQs suggests their different regulatory capacities for processes associated with human telomeres.
Bibliography:	NSF - No. CHE-1026532 Cancer Research U.K. ark:/67375/WNG-GFX0XD9C-F istex:8ECB84B96642C35EDE7A31B76558381835C6D597 ArticleID:CBIC201300350 These authors contributed equally to this work. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.201300350