New Friedelane Triterpenoids with Antimicrobial Activity from the Stems of Drypetes paxii

• Published in: Chemical & pharmaceutical bulletin Vol. 57; no. 10; pp. 1119 - 1122
• Main Authors: Chiozem, David Dako, Trinh-Van-Dufat, Hanh, Wansi, Jean Duplex, Djama, Céline Mbazoa, Fannang, Véronique Simone, Seguin, Elisabeth, Tillequin, François, Wandji, Jean
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01-10-2009; Japan Science and Technology Agency
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; antimicrobial activity; Disk Diffusion Antimicrobial Tests; Drypetes; Drypetes paxii; Euphorbiaceae; Euphorbiaceae - chemistry; friedelane-type triterpenoid; Magnetic Resonance Spectroscopy; Molecular Conformation; Plant Stems - chemistry; stem; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.57.1119

Two new friedelane-type triterpenes named 12α-hydroxyfriedelane-3,15-dione and 3β-hydroxyfriedelan-25-al, together with six known compounds were isolated from the stems of Drypetes paxii HUTCH. (Euphorbiaceae). Their structures were established on the basis of conventional 1 dimensional (1D) NMR methods, 2D shift-correlated NMR experiments and mass spectra. The five friedelane-type triterpene derivatives and one olean-12-ene triterpene saponin were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and they appeared to be modestly active.