Determination of the effects of Alcohol Dehydrogenase (ADH) 1B and ADH1C polymorphisms on alcohol dependence in Turkey

• Published in: Science & justice Vol. 52; no. 1; pp. 58 - 61
• Main Authors: Aktas, Ekin Ozgur, Kocak, Aytaç, Senol, Ender, Celik, Handan Ak, Coskunol, Hakan, Berdeli, Afig, Aydin, Hikmet Hakan
• Format: Journal Article
• Language: English
• Published: England Elsevier Ireland Ltd 01-03-2012; Forensic Science Society
• Subjects: ADH1B; ADH1C; Adult; Alcohol Dehydrogenase - genetics; Alcohol dependence; Alcoholism; Alcoholism - enzymology; Alcoholism - genetics; Alleles; Case-Control Studies; Chi-Square Distribution; Gene polymorphism; Genes; Genotype; Genotype & phenotype; Humans; Hydrogenases; Male; Pathology; Polymorphism; Polymorphism, Single Nucleotide; Turkey; Turkey; ADH1C; Hardy–Weinberg equilibrium; ADH1B; alcohol dehydrogenase 1 B (class 1) beta polypeptide; Linkage disequilibrium; alcohol dehydrogenase 1 C (class I) gamma polypeptide; HWE; LD; Alcohol dependence; Gene polymorphism
• ISSN: 1355-0306; 1876-4452
• DOI: 10.1016/j.scijus.2011.05.002

Abstract Alcoholism is a complex genetically influenced disorder which refers to alcohol abuse and alcohol dependence. There are controversial results on the role of gene polymorphisms in alcohol dependence in the literature. Differences in population groups and selective inclusion criteria for alcohol dependence may affect results. In this study, we investigated the role of ADH1B Arg48His (rs1229984) and, ADH1C Ile350Val (rs698) gene polymorphisms in Turkish population. 100 healthy volunteers and 75 patients who were admitted to Ege University Alcohol Dependence Unit enrolled in the study. We found significant increase both in ADH1B (Arg48His) polymorphism Arg allele and Arg/Arg genotype frequency in patients. No profound connection between alcohol dependence and ADH1C Ile350Val gene polymorphism was detected. Alcohol dependence is an important health problem that depends on many genetic and environmental factors but we think that it is possible to interpret genetic risk for developing early diagnostic methods and treatment strategies by comprehensive linkage and association studies.