Pharmaceutical assessment of polyvinylpyrrolidone (PVP): As excipient from conventional to controlled delivery systems with a spotlight on COVID-19 inhibition

• Published in: Journal of drug delivery science and technology Vol. 60; p. 102046
• Main Authors: Kurakula, Mallesh, Rao, G.S.N. Koteswara
• Format: Journal Article
• Language: English
• Published: France Elsevier B.V 01-12-2020
• Subjects: Controlled release; Conventional dosage forms; COVID 19; Drug delivery; Excipient; Polymer; Polyvinylpyrrolidone; Povidone-iodine; Review; Povidone-iodine; Polymer; Excipient; Polyvinylpyrrolidone; Drug delivery; Conventional dosage forms; COVID 19; Controlled release; Polyvinylpyrrolidone, PVP
• ISSN: 1773-2247; 2588-8943
• DOI: 10.1016/j.jddst.2020.102046

Polyvinylpyrrolidone (PVP) is a water-soluble polymer obtained by polymerization of monomer N-vinylpyrrolidone. PVP is an inert, non-toxic, temperature-resistant, pH-stable, biocompatible, biodegradable polymer that helps to encapsulate and cater both hydrophilic and lipophilic drugs. These advantages enable PVP a versatile excipient in the formulation development of broad conventional to novel controlled delivery systems. PVP has tunable properties and can be used as a brace component for gene delivery, orthopedic implants, and tissue engineering applications. Based on different molecular weights and modified forms, PVP can lead to exceptional beneficial features with varying chemical properties. Graft copolymerization and other techniques assist PVP to conjugate with poorly soluble drugs that can inflate bioavailability and even introduces the desired swelling tract for their control or sustained release. The present review provides chemistry, mechanical, physicochemical properties, evaluation parameters, dewy preparation methods of PVP derivatives intended for designing conventional to controlled systems for drug, gene, and cosmetic delivery. The past and growing interest in PVP establishes it as a promising polymer to enhance the trait and performance of current generation pharmaceutical dosage forms. Furthermore, the scrutiny explores existing patents, marketed products, new and futuristic approaches of PVP that have been identified and scope for future development, characterization, and its use. The exploration spotlights the importance and role of PVP in the design of Povidone-iodine (PVP–I) and clinical trials to assess therapeutic efficacy against the COVID-19 in the current pandemic scenario.
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•Scrutiny of recent advances and trends of PVP in multidisciplinary pharmaceutical applications.•Clinical trials and discussion on broad PVP utilization against pandemic COVID-19.•Futuristic PVP based conventional to controlled drug delivery systems are covered.•Patent prospection on the PVP based drug delivery systems till date.•Comprehensive list of marketed PVP based pharmaceutical products.