Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways

• Published in: Journal of industrial microbiology & biotechnology Vol. 41; no. 2; pp. 219 - 232
• Main Author: Challis, Gregory L
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01-02-2014; Springer Berlin Heidelberg; Oxford University Press
• Subjects: Actinobacteria; Analysis; Anti-Bacterial Agents - biosynthesis; Anti-Bacterial Agents - chemistry; Antibiotics; bioactive properties; Bioassays; biochemical pathways; Biochemistry; Bioinformatics; Biological Products - chemistry; Biological Products - metabolism; Biomedical and Life Sciences; Biosynthesis; Biosynthetic Pathways - genetics; Biotechnology; Chromosomes; Cloning; Genes; Genetic Engineering; Genome, Bacterial; Genomes; Genomics; Inorganic Chemistry; Life Sciences; Metabolites; Microbiology; Natural products; nucleotide sequences; Peptides; Plasmids; Proteins; Review; Sequence Analysis, DNA; Streptomyces; Streptomyces coelicolor; Streptomyces coelicolor - genetics; Streptomyces coelicolor - metabolism; Streptomycetes; Studies; Polyketide synthase; Nonribosomal peptide synthetase; Antibiotic; Terpene synthase; Siderophore
• ISSN: 1367-5435; 1476-5535
• DOI: 10.1007/s10295-013-1383-2

Streptomyces, and related genera of Actinobacteria, are renowned for their ability to produce antibiotics and other bioactive natural products with a wide range of applications in medicine and agriculture. Streptomyces coelicolor A3(2) is a model organism that has been used for more than five decades to study the genetic and biochemical basis for the production of bioactive metabolites. In 2002, the complete genome sequence of S. coelicolor was published. This greatly accelerated progress in understanding the biosynthesis of metabolites known or suspected to be produced by S. coelicolor and revealed that streptomycetes have far greater potential to produce bioactive natural products than suggested by classical bioassay-guided isolation studies. In this article, efforts to exploit the S. coelicolor genome sequence for the discovery of novel natural products and biosynthetic pathways are summarized.