The effect of epidural somatostatin on postoperative pain

• Published in: Anesthesia and analgesia Vol. 64; no. 11; pp. 1085 - 1088
• Main Authors: CHRUBASIK, J, MEYNADIER, J, SCHERPEREEL, P, WÜNSCH, E
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott 01-01-1985
• Subjects: Aged; Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Chemical Analysis; Catheterization; Epidural Space; Female; Hemodynamics - drug effects; Humans; Infusions, Parenteral; Injections; Local anesthesia. Pain (treatment); Male; Medical sciences; Middle Aged; Naloxone - pharmacology; Pain, Postoperative - drug therapy; Respiration - drug effects; Somatostatin - administration & dosage; Somatostatin - antagonists & inhibitors; Somatostatin - therapeutic use; Human; Postoperative; Pain; Treatment; Extradural administration; Anesthesia; Complication; Somatostatin
• ISSN: 0003-2999; 1526-7598
• DOI: 10.1213/00000539-198511000-00009

The epidural injection of a bolus of 250 micrograms somatostatin followed by continuous epidural infusion provided complete postoperative relief of pain in eight patients who had undergone abdominal surgery; no other analgesics were required. In two patients, intravenous and intramuscular naloxone had no effect on the analgesia provided by epidural somatostatin. In two patients, epidural somatostatin also produced adequate intraoperative analgesia. Epidural somatostatin was associated with no side effects.