Genetic association analysis of 5‐HTR2A gene variants in eating disorders in a Mexican population

• Published in: Brain and behavior Vol. 9; no. 7; pp. e01286 - n/a
• Main Authors: Genis‐Mendoza, Alma Delia, Ruiz‐Ramos, David, López‐Narvaez, María Lilia, Tovilla‐Zárate, Carlos Alfonso, Rosa García, Ana, Cortes Meda, Gabriela, Martinez‐Magaña, José Jaime, González‐Castro, Thelma Beatriz, Juárez‐Rojop, Isela Esther, Nicolini, Humberto
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-07-2019; John Wiley and Sons Inc; Wiley
• Subjects: 5HTR2A gene; Adult; Anorexia; Blood & organ donations; Bulimia; Case-Control Studies; Comorbidity; Consent; Eating behavior; Eating disorders; Epigenetics; Feeding and Eating Disorders - epidemiology; Feeding and Eating Disorders - genetics; Female; Gene; Genetic Predisposition to Disease; Haplotypes; Humans; Impulsivity; Male; Mental disorders; Mexican population; Mexico - epidemiology; Middle Aged; Original Research; Parents & parenting; Polymorphism; Polymorphism, Single Nucleotide; Population; Receptor, Serotonin, 5-HT2A - genetics; Serotonin; Suicide, Attempted - prevention & control; Suicide, Attempted - statistics & numerical data; Tutoring; Twins; Mexico; Mexican population; Gene; Serotonin; 5HTR2A gene
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1286

Introduction
The 5‐HTR2A gene has been implicated as candidate gene for eating disorders. The aim of the present study was to analyze the association of rs6311 and rs6313 polymorphisms of 5‐HTR2A gene with eating disorders in Mexican population, and to evaluate if the polymorphisms of 5‐HTR2A gene were associated with comorbidities in eating behavior.
Methods
We conducted a case–control analysis with 460 subjects. We included 168 patients with eating disorders and 292 controls; two polymorphisms of 5‐HTR2A gene were genotyped. We assessed the association by allele, genotype, and inheritance models. Psychiatric comorbidities were analyzed by genotype in patients with eating disorders.
Results
We found an association between rs6311 and eating disorders in a Mexican population by allele (OR = 8.09; 95% CI = 5.99–11.03; p = 2.2e‐16) and genotype (OR = 76.14; 95% CI = 35.61–177.18; p = 2.2e‐16). Individuals who carried GG genotype showed increased risk for suicide attempted (OR = 2.14; CI = 1.10–4.26; p = 0.035) as comorbidity associated with eating disorders. No positive associations were observed for rs6313 polymorphism.
Conclusion
Our results showed an association of rs6311 (A1438G) polymorphism of 5‐HTR2A gene with eating disorders, and these polymorphic variants could increase the risk of psychiatric comorbidities. However, more studies are required to replicate the results and to reach to a conclusive association between eating disorders and rs6311.
We evaluated the association of polymorphisms of 5‐HTR2A gene with eating disorders in Mexican population. We found an association of rs6311 (A1438G) polymorphism of 5‐HTR2A gene with eating disorders. The rs6311 could increase the risk of psychiatric comorbidities in patient with eating disorders.