Oligoethylene Glycols as Highly Efficient Mutifunctional Promoters for Nucleophilic-Substitution Reactions

• Published in: Chemistry : a European journal Vol. 18; no. 13; pp. 3918 - 3924
• Main Authors: Jadhav, Vinod H., Jang, Seung Ho, Jeong, Hwan-Jeong, Lim, Seok Tae, Sohn, Myung-Hee, Kim, Ju-Young, Lee, Sungyul, Lee, Ji Woong, Song, Choong Eui, Kim, Dong Wook
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 26-03-2012; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Acetates; Alcohols - chemistry; alkali metals; Catalysis; Cations; Chemistry; Combinatorial Chemistry Techniques; Ethylenes - chemistry; Fluorination; fluorine; Fluorine - chemistry; Glycols; Glycols - chemistry; Metals, Alkali - chemistry; Molecular Conformation; Molecular Structure; multifunctional promoter; Nucleophiles; nucleophilic substitution; oligoethylene glycol; Potassium; Quantum chemistry; Substrates
• ISSN: 0947-6539; 1521-3765
• DOI: 10.1002/chem.201102455

Herein, we report the promising use of n‐oligoethylene glycols (oligoEGs) as mutifunctional promoters for nucleophilic‐substitution reactions employing alkali metal salts. Among the various oligoEGs tested, pentaethylene glycol (pentaEG) had the most efficient catalytic activity. In particular, when compared with other nucleophiles examined, a fluorine nucleophile generated from CsF was significantly activated by the pentaEG promoter. We also performed various facile nucleophilic‐displacement reactions, such as the halogenation, acetoxylation, thioacetoxylation, nitrilation, and azidation of various substrates with potassium halides, acetate, thioacetate, cyanide, and sodium azide, respectively, in the presence of the pentaEG promoter. All of these reactions provided their desired products in excellent yields. Furthermore, the combination of pentaEG and a tert‐alcohol medium showed tremendous efficiency in the nucleophilic‐displacement reactions (fluorination and methoxylation) of base‐sensitive substrates with basic nucleophiles (cesium fluoride and potassium methoxide, respectively). The catalytic role of oligoEGs was examined by quantum‐chemical methods. The oxygen atoms in oligoEGs were found to act as Lewis bases on the metal cations to produce the “flexible” nucleophile, whereas the two terminal hydroxy (OH) groups acted as “anchors” to orientate the nucleophile and the substrate into an ideal configuration for the reaction.
The EG race: OligoEGs, such as pentaethylene glycol (pentaEG), act as mutifunctional promoters for nucleophilic‐substitution reactions with the corresponding alkali‐metal salts. The combination of pentaEG and a tert‐alcohol media system showed tremendous efficiency in the fluorination and methoxylation of base‐sensitive substrates by using the corresponding basic nucleophiles (see figure).