Electrocorticographic description of the effects of anticonvulsant drugs used to treat lidocaine‐induced seizures

• Published in: Brain and behavior Vol. 11; no. 2; pp. e01940 - n/a
• Main Authors: Santos, George Francisco S., Ferreira, Luan Oliveira, Gerrits Mattos, Bruna, Fidelis, Eliniete J., Souza, Alisson S., Batista, Paula S., Manoel, Cecilia A. F., Cabral, Diego Arthur C., Jóia de Mello, Vanessa, Favacho Lopes, Dielly Catrina, Hamoy, Moisés
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01-02-2021; John Wiley and Sons Inc; Wiley
• Subjects: Akinesia; Anticonvulsants; Behavior; Convulsions & seizures; Drug dosages; electrocorticography; electromyography; epilepsy; Laboratory animals; lidocaine; Original Research; seizure; epilepsy; electrocorticography; seizure; electromyography; lidocaine
• ISSN: 2162-3279; 2162-3279
• DOI: 10.1002/brb3.1940

Introduction
Local anesthetics are widely used in clinical practice. While toxicity is rare, these drugs can cause potentially lethal seizures.
Objective
In the present study, we investigated the electrocorticographic (ECoG) and electromyographic patterns of seizures induced by acute lidocaine (LA) toxicity and treated with anticonvulsant drugs. The study used adult male Wistar rats to describe of the seizure‐related behavior of LA and investigated the treatment with anticonvulsant drugs.
Results
The use of LA resulted in clear changes in the ECoG pattern, which presented characteristics of Status epilepticus, with increased intensity in all brainwaves. The decomposition of the cerebral waves showed an increase in the beta and gamma waves that may be related to tonic–clonic seizure. Although the treatment with anticonvulsants drugs reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group, but only diazepam (DZP) was able to decrease the intensity of oscillations. The muscle contraction power also indicated a difference in the effectiveness of the three treatments.
Conclusion
The sum of the evidence indicates that LA causes status epilepticus and that DZP is the most effective treatment for the control of these seizures, by restoring the systemic values to levels close to those recorded in the control group.
Lidocaine (LA) intraperitoneally resulted in changes in the electrocorticographic pattern, with characteristics of Status epilepticus. Treatment with diazepam reduces the power of brainwaves at frequencies between 1 and 40 Hz compared to the LA group.