The Role of CLEC-2 and Its Ligands in Thromboinflammation

C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 12; p. 688643
Main Authors:	Meng, Danyang, Luo, Man, Liu, Beibei
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 09-06-2021
Subjects:	CLEC-2 Immunology inflammation podoplanin thromboinflammation thrombosis
Online Access:	Get full text
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Summary:	C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 This article was submitted to Inflammation, a section of the journal Frontiers in Immunology Edited by: Fabrice Cognasse, Groupe Sur L’immunité Des Muqueuses Et Agents Pathogènes (GIMAP), France Reviewed by: Julie Rayes, University of Birmingham, United Kingdom; Philipp von Hundelshausen, Ludwig Maximilian University of Munich, Germany
ISSN:	1664-3224 1664-3224
DOI:	10.3389/fimmu.2021.688643