Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases

• Published in: Microorganisms (Basel) Vol. 10; no. 12; p. 2382
• Main Authors: Effendi, Raden Mohamad Rendy Ariezal, Anshory, Muhammad, Kalim, Handono, Dwiyana, Reiva Farah, Suwarsa, Oki, Pardo, Luba M, Nijsten, Tamar E C, Thio, Hok Bing
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30-11-2022; MDPI
• Subjects: Akkermansia; Akkermansia muciniphila; Atopic dermatitis; Bacteria; Cancer; Cancer immunotherapy; Chronic conditions; Chronic illnesses; Dermatitis; Digestive system; Disease; Disorders; Faecalibacterium; Faecalibacterium prausnitzii; Gastrointestinal tract; HIV; Homeostasis; Human immunodeficiency virus; Immune system; immune-related diseases; Immunological diseases; Immunology; Immunotherapy; Inflammation; Inflammatory bowel disease; Inflammatory response; Intestinal microflora; Metabolism; Metabolites; Microbiomes; Microbiota; Microorganisms; Nervous system; Physiology; Prebiotics; Probiotics; Psoriasis; Review; Skin diseases; Systemic lupus erythematosus; Therapeutic targets; systemic lupus erythematosus; immune-related diseases; psoriasis; immunotherapy; human immunodeficiency virus; Faecalibacterium prausnitzii; atopic dermatitis; Akkermansia muciniphila; probiotics
• ISSN: 2076-2607; 2076-2607
• DOI: 10.3390/microorganisms10122382

Probiotics and synbiotics are used to treat chronic illnesses due to their roles in immune system modulation and anti-inflammatory response. They have been shown to reduce inflammation in a number of immune-related disorders, including systemic lupus erythematosus (SLE), human immunodeficiency virus (HIV), and chronic inflammatory skin conditions such as psoriasis and atopic dermatitis (AD).
(
) and
(
) are two different types of bacteria that play a significant part in this function. It has been established that
and
are abundant in normal populations and have protective benefits on digestive health while also enhancing the immune system, metabolism, and gut barrier of the host. They have the potential to be a therapeutic target in diseases connected to the microbiota, such as immunological disorders and cancer immunotherapy. There has not been a review of the anti-inflammatory effects of
and
, particularly in immunological diseases. In this review, we highlight the most recent scientific findings regarding
and
as two significant gut microbiota for microbiome alterations and seek to provide cutting-edge insight in terms of microbiome-targeted therapies as promising preventive and therapeutic tools in immune-related diseases and cancer immunotherapy.