Day-5 inhibin B serum concentrations and antral follicle count as predictors of ovarian response and live birth in assisted reproduction cycles stimulated with gonadotropin after pituitary suppression

• Published in: Fertility and sterility Vol. 94; no. 7; pp. 2590 - 2595
• Main Authors: Peñarrubia, Joana, M.D, Peralta, Sara, M.D, Fábregues, Francisco, M.D, Carmona, Francisco, M.D, Casamitjana, Roser, M.D, Balasch, Juan, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-12-2010; Elsevier
• Subjects: Adult; AFC; Biological and medical sciences; Birth control; Cell Count; Down-Regulation - drug effects; Female; Gonadotropins - therapeutic use; Gynecology. Andrology. Obstetrics; Humans; Infant, Newborn; Infertility - blood; Infertility - diagnosis; Infertility - epidemiology; Infertility - therapy; inhibin B; Inhibins - analysis; Inhibins - blood; Internal Medicine; IVF; Live Birth - epidemiology; Medical sciences; Obstetrics and Gynecology; Osmolar Concentration; Ovarian Follicle - drug effects; Ovarian Follicle - pathology; Ovulation Induction - methods; Pituitary Gland - drug effects; Pituitary Gland - physiology; poor responders; Pregnancy; Prognosis; Reproductive Techniques, Assisted; Sterility. Assisted procreation; Time Factors; IVF; poor responders; inhibin B; AFC; Gynecology; Inhibin; Assisted procreation; Concentration; Gonadotropin; Birth; Obstetrics; Antral follicle; In vitro fertilization embryo transfer; Ovary; Pituitary gland; Serum; Predictive factor; Ovarian follicle
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/j.fertnstert.2010.03.009

Objective To investigate the usefulness of day-5 inhibin B and antral follicle count (AFC) in predicting ovarian response and live birth in the first cycle of assisted reproduction. Design Prospective c ohort study. Setting University hospital. Patient(s) Ninety-eight infertile women treated with in vitro fertilization–intracytoplasmic sperm injection (IVF–ICSI) comprising 72 normal responders and 26 poor responders. Intervention(s) Ovarian stimulation with gonadotropin-releasing hormone agonist-gonadotropin treatment. Main Outcome Measure(s) Basal ultrasonographic (AFC, total ovarian volume) and basal (follicle-stimulating hormone, estradiol, and inhibin B) and stimulation day-5 (estradiol, inhibin B) hormone parameters. Result(s) The AFC had the best predictive value among the basal variables for outcome of ovarian stimulation. Among the dynamic hormone measurements, day-5 inhibin serum measurement emerged as the best predictive variable of poor response in IVF–ICSI cycles, but it was not statistically significantly better than basal AFC. The association of day-5 inhibin B with live-birth rate was statistically significant and stronger than the effect of any other variable investigated. Conclusion(s) Basal AFC and day-5 inhibin B have similar predictive properties for ovarian response in assisted reproduction cycles stimulated with gonadotropin after pituitary suppression, but day-5 inhibin B is a superior predictor of live birth.