Treatment satisfaction, preferences and perception gaps between patients and physicians in the ulcerative colitis CARES study: A real world-based study

• Published in: Digestive and liver disease Vol. 48; no. 6; pp. 601 - 607
• Main Authors: Peyrin-Biroulet, Laurent, Van Assche, Gert, Sturm, Andreas, Gisbert, Javier P, Gaya, Daniel R, Bokemeyer, Bern, Mantzaris, Gerassimos J, Armuzzi, Alessandro, Sebastian, Shaji, Lara, Nuria, Lynam, Mark, Rojas-Farreras, Sonia, Fan, Tao, Ding, Qian, Black, Christopher M, Kachroo, Sumesh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-06-2016; Elsevier
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Colitis, Ulcerative - drug therapy; Cross-Sectional Studies; Europe; Female; Gastroenterology and Hepatology; Health Knowledge, Attitudes, Practice; Humans; Inflammatory bowel disease; Life Sciences; Logistic Models; Male; Middle Aged; Multivariate Analysis; Patient Satisfaction; Physician-Patient Relations; Physicians; Quality of Life; Retrospective Studies; Severity of Illness Index; Surveys and Questionnaires; Unmet needs; Inflammatory bowel disease; Unmet needs; Perspective; Trial; Inflammatory-Bowel-Disease; Needs; Online Survey; Management
• ISSN: 1590-8658; 1878-3562
• DOI: 10.1016/j.dld.2016.01.013

Abstract Background Ulcerative colitis (UC) is a life time disease and issues with therapy may impact on patient satisfaction and treatment preferences. Aims To assess disease and treatment perception gaps from patients’ and physicians’ perspectives in UC patients. Methods Adult patients with moderate-to-severe UC (Mayo score ≥6) naïve to biologic therapy were enrolled in a European, observational, cross-sectional, retrospective study. Treatment satisfaction was assessed by the TSQM questionnaire and treatment preferences and patient's knowledge with pre-defined questions. Physicians’ and patients’ perceptions were compared through the level of agreement. Results 256 patients from 11 European countries were included. 48.0% of patients were dissatisfied with their current treatment. Effectiveness, long lasting action, rapid start of action, and fewer side effects were the attributes more frequently considered important or very important by patients (96.9%, 89.1%, 83.8%, and 81.8%, respectively). 26.2% patients rated their overall disease knowledge as very knowledgeable. The agreement between patients’ and physicians on disease severity was good (kappa = 0.62). Conclusion Half patients with moderate-to-severe UC managed with conventional therapy, are dissatisfied with their treatments. Effectiveness, long lasting action and rapidity of action were the most frequently rated items in treatment preferences. There are major gaps between physicians and patients when evaluating disease burden.