Animal models and measures of perceptual processing in Schizophrenia

• Published in: Neuroscience and biobehavioral reviews Vol. 37; no. 9; pp. 2092 - 2098
• Main Authors: Siegel, Steven J., Talpos, John C., Geyer, Mark A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01-11-2013
• Subjects: Animals; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Cognition Disorders - therapy; Disease Models, Animal; Event related potentials; Humans; Inhibition (Psychology); Mismatch negative; Nonlinear Dynamics; Perceptual Disorders - diagnosis; Perceptual Disorders - etiology; Photic Stimulation; Prepulse inhibition of startle; Reproducibility of Results; Schizophrenia - complications; Visual integration; Visual integration; Prepulse inhibition of startle; Mismatch negative; Event related potentials
• ISSN: 0149-7634; 1873-7528
• DOI: 10.1016/j.neubiorev.2013.06.016

•Discusses animal paradigms for assessing perception.•CNTRICS breakout group addressed candidate tests of perception.•Concepts included gain control and visual integration.•Comparability of tasks across species was discussed.•Criteria included validity; homology and dynamic range.
This paper summarizes the discussions regarding animal paradigms for assessing perception at the seventh meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS). A breakout group at the meeting addressed candidate tests in animals that might best parallel the human paradigms selected previously in the CNTRICS program to assess two constructs in the domain of perception: gain control and visual integration. The perception breakout group evaluated the degree to which each of the nominated tasks met pre-specified criteria: comparability of tasks across multiple species; construct validity; neuroanatomical homology between species; and dynamic range across parametric variation.