Functional genome of the human pathogenic fungus Paracoccidioides brasiliensis

• Published in: FEMS immunology and medical microbiology Vol. 45; no. 3; pp. 369 - 381
• Main Authors: Felipe, Maria Sueli S., Torres, Fernando A.G., Maranhão, Andrea Q., Silva-Pereira, Ildinete, Poças-Fonseca, Marcio J., Campos, Elida G., Moraes, Lídia M.P., Arraes, Fabrício B.M., Carvalho, Maria José A., Andrade, Rosângela V., Nicola, André M., Teixeira, Marcus M., Jesuíno, Rosália S.A., Pereira, Maristela, Soares, Célia M.A., Brígido, Marcelo M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier B.V 01-09-2005; Blackwell Publishing Ltd
• Subjects: Cell differentiation; Expressed Sequence Tags; Functional genomics; Fungal Proteins - genetics; Fungal Proteins - metabolism; Gene Expression Regulation, Fungal; Genome, Fungal; Host–pathogen interaction; Humans; Metabolism; Paracoccidioides - genetics; Paracoccidioides - growth & development; Paracoccidioides - metabolism; Paracoccidioides - pathogenicity; Paracoccidioides brasiliensis; Paracoccidioidomycosis - microbiology; Transcription, Genetic; Transcriptome; Host–pathogen interaction; Metabolism; Cell differentiation; Functional genomics; Transcriptome; Paracoccidioides brasiliensis; Host-pathogen interaction
• ISSN: 0928-8244; 1574-695X
• DOI: 10.1016/j.femsim.2005.05.013

Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America. Pathogenicity is assumed to be a consequence of the cellular differentiation process that this fungus undergoes from mycelium to yeast cells during human infection. In an effort to elucidate the molecular mechanisms involved in this process a network of Brazilian laboratories carried out a transcriptome project for both cell types. This review focuses on the data analysis yielding a comprehensive view of the fungal metabolism and the molecular adaptations during dimorphism in
P. brasiliensis from analysis of 6022 groups, related to expressed genes, which were generated from both mycelium and yeast phases.