Muconic acid in urine: a reliable indicator of occupational exposure to benzene

In male subjects not occupationally exposed to benzene, the concentration of muconic acid (MA) in urine is usually below 0.5 mg/g creatinine. At ambient levels of benzene exposure (below 0.01 ppm), the mean MA level was greater in 21 smokers than in 14 nonsmokers. In 38 male subjects employed in gar...

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Bibliographic Details
Published in:	American journal of industrial medicine Vol. 25; no. 2; p. 297
Main Authors:	Lauwerys, R R, Buchet, J P, Andrien, F
Format:	Journal Article
Language:	English
Published:	United States 01-02-1994
Subjects:	Adult Air Pollutants, Occupational - analysis Air Pollutants, Occupational - metabolism Benzene - analysis Benzene - metabolism Biomarkers - urine Humans Male Occupational Exposure - analysis Smoking - urine Sorbic Acid - analogs & derivatives Sorbic Acid - analysis Sorbic Acid - metabolism Urine - chemistry
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Summary:	In male subjects not occupationally exposed to benzene, the concentration of muconic acid (MA) in urine is usually below 0.5 mg/g creatinine. At ambient levels of benzene exposure (below 0.01 ppm), the mean MA level was greater in 21 smokers than in 14 nonsmokers. In 38 male subjects employed in garages and coke ovens, a statistically significant correlation was found between the airborne concentration of benzene measured with passive monitors and MA in postshift urine. The mean postshift MA concentrations corresponding to a benzene 8-hour time-weighted average exposure (TWA) of 0.5 and 1 ppm were 0.8 and 1.4 mg/g creatinine, respectively.
ISSN:	0271-3586
DOI:	10.1002/ajim.4700250216