Açai supplementation (Euterpe oleracea Mart.) attenuates cardiac remodeling after myocardial infarction in rats through different mechanistic pathways

• Published in: PloS one Vol. 17; no. 3; p. e0264854
• Main Authors: Figueiredo, Amanda Menezes, Cardoso, Ana Carolina, Pereira, Bruna Leticia Buzati, Silva, Renata Aparecida Candido, Ripa, Andrea Freitas Goncalves Della, Pinelli, Tatiana Fernanda Bachiega, Oliveira, Bruna Camargo, Rafacho, Bruna Paola Murino, Ishikawa, Larissa Lumi Watanabe, Azevedo, Paula Schmidt, Okoshi, Katashi, Fernandes, Ana Angelica Henrique, Zornoff, Leonardo Antonio Mamede, Minicucci, Marcos Ferreira, Polegato, Bertha Furlan, Paiva, Sergio Alberto Rupp
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04-03-2022; Public Library of Science (PLoS)
• Subjects: Acai berries; Animal models in research; Animals; Anti-inflammatory agents; Antioxidants; Antioxidants - metabolism; Antioxidants - pharmacology; Attenuation; Biochemistry; Biology and Life Sciences; Collagen; Coronary vessels; Dietary Supplements; Echocardiography; Energy metabolism; Euterpe; Euthanasia; Evaluation; Functional foods & nutraceuticals; Health aspects; Heart attack; Heart attacks; Inflammation; Interleukin 10; Internal medicine; Laboratory animals; Lipids; Male; Malondialdehyde; Medical schools; Medicine; Medicine and Health Sciences; Metabolism; Mortality; Myocardial infarction; Myocardial Infarction - drug therapy; Natural products; Ostomy; Oxidative metabolism; Oxidative stress; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Polyphenols; Pulp; Rats; Rats, Wistar; Risk factors; Seeds; Stress concentration; Ventricular Remodeling; Brazil
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0264854

Myocardial infarction has a high mortality rate worldwide. Therefore, clinical intervention in cardiac remodeling after myocardial infarction is essential. Açai pulp is a natural product and has been considered a functional food because of its antioxidant/anti-inflammatory properties. The aim of the present study was to analyze the effect of açai pulp supplementation on cardiac remodeling after myocardial infarction in rats. After 7 days of surgery, male Wistar rats were assigned to six groups: sham animals fed standard chow (SA0, n = 14), fed standard chow with 2% açai pulp (SA2, n = 12) and fed standard chow with 5% açai pulp (SA5, n = 14), infarcted animals fed standard chow (IA0, n = 12), fed standard chow with 2% açai pulp (IA2, n = 12), and fed standard chow with 5% açai pulp (IA5, n = 12). After 3 months of supplementation, echocardiography and euthanasia were performed. Açai pulp supplementation, after myocardial infarction, improved energy metabolism, attenuated oxidative stress (lower concentration of malondialdehyde, P = 0.023; dose-dependent effect), modulated the inflammatory process (lower concentration of interleukin-10, P<0.001; dose-dependent effect) and decreased the deposit of collagen (lower percentage of interstitial collagen fraction, P<0.001; dose-dependent effect). In conclusion, açai pulp supplementation attenuated cardiac remodeling after myocardial infarction in rats. Also, different doses of açai pulp supplementation have dose-dependent effects on cardiac remodeling.