High-sensitivity cardiac troponin T in essential hypertension

• Published in: Journal of cardiology Vol. 58; no. 3; pp. 226 - 231
• Main Authors: Sato, Yukihito, MD, PhD, FJCC, Yamamoto, Erika, MD, Sawa, Takuma, MD, Toda, Keizo, Hara, Tomoko, Iwasaki, Toshiaki, Fujiwara, Hisayoshi, MD, PhD, FJCC, Takatsu, Yoshiki, MD, PhD
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01-11-2011
• Subjects: Adult; Age Factors; Aged; Aged, 80 and over; Biomarker; Biomarkers - blood; Cardiovascular; Electrocardiography; Female; Glomerular Filtration Rate; Heart failure; Heart Failure - diagnosis; High-sensitivity troponin; Humans; Hypertension; Hypertension - diagnosis; Male; Middle Aged; Multivariate Analysis; Myocyte injury; Prognosis; Sensitivity and Specificity; Troponin T - blood; Heart failure; Hypertension; Biomarker; Myocyte injury; High-sensitivity troponin
• ISSN: 0914-5087; 1876-4738
• DOI: 10.1016/j.jjcc.2011.07.009

Summary Background Myocyte injury might be involved in the progression of essential hypertension (EHT) toward heart failure (HF). However, in the absence of high-sensitivity (hs) assay, cardiac troponin T (TnT) in EHT has not been measurable. Methods and results We studied 236 consecutive ambulatory patients (mean age = 65.5 years; 110 men) with treated EHT (mean systolic blood pressure = 134.3 mmHg, mean serum N-terminal pro-B-type natriuretic peptide = 86.6 pg/ml) for mean 65.6 months. Patients with a history of HF were excluded. Single and multiple variable analyses were performed in search of clinical correlates of elevated hs-TnT (≥0.003 ng/ml). Serum concentration of hs-TnT was ≥0.003 ng/ml (mean = 0.008 ng/ml) in 184 patients. By single variable analysis, age, uric acid, log-transformed N-terminal pro-B-type natriuretic peptide, brachial-ankle pulse wave velocity, Cornell electrocardiographic (ECG) voltage, and number of antihypertensive medications were associated with log-transformed hs-TnT, while hemoglobin and estimated glomerular filtration rate (eGFR) were inversely correlated with log-transformed hs-TnT. By multivariate analysis, age, eGFR and Cornell voltage were independent correlates of log-transformed hs-TnT, even after adjustment for clinical backgrounds including known prognostic biomarkers of EHT. Conclusions hs-TnT was ≥0.003 ng/ml in 78% of patients presenting with treated EHT and independently correlated with age, renal function, and ECG voltage of hypertrophy.