High potency vaccines induce protection against heterologous challenge with foot-and-mouth disease virus

• Published in: Vaccine Vol. 26; no. 13; pp. 1681 - 1687
• Main Authors: Brehm, K.E, Kumar, N, Thulke, H.-H, Haas, B
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 20-03-2008; Elsevier; Elsevier Limited
• Subjects: Allergy and Immunology; Animal diseases; Animals; Antigens; Biological and medical sciences; Cattle; Cattle Diseases - immunology; Cattle Diseases - prevention & control; Dose-Response Relationship, Immunologic; Enzyme-Linked Immunosorbent Assay; Female; Foot & mouth disease; Foot-and-Mouth Disease - immunology; Foot-and-Mouth Disease - prevention & control; Foot-and-mouth disease virus; Foot-and-Mouth Disease Virus - immunology; Fundamental and applied biological sciences. Psychology; Male; Microbiology; Mortality; Neutralization Tests; Protection by vaccines; Serology; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Viral Vaccines - immunology; Virology; United Kingdom > UK; Protection by vaccines; Foot-and-mouth disease virus; Serology; Virus; Immunoprotection; Aphthovirus; Picornaviridae; Vaccine; Veterinary
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2008.01.038

Summary In a series of three homologous and eight heterologous challenge experiments, it was shown that high potency vaccines against foot-and-mouth disease (FMD) serotype A can induce protection even against heterologous challenge infection with viruses that give low r -values with the vaccine strains. The challenge virus specific neutralizing antibody response on the day of challenge (21 days post vaccination) generally correlated with protection.