Effects of Astragalus polysaccharides on memory impairment in a diabetic rat model

• Published in: Neuropsychiatric disease and treatment Vol. 12; pp. 1617 - 1621
• Main Authors: Dun, Changping, Liu, Junqian, Qiu, Fucheng, Wu, Xueda, Wang, Yakun, Zhao, Yongyan, Gu, Ping
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2016; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Astragalus (Plants); Blood glucose; Brain research; Complications and side effects; Diabetes; Drug dosages; Drug therapy; Glucose; Hyperglycemia; Insulin resistance; Ischemia; Laboratory animals; Maternal & child health; Memory; Memory, Disorders of; Original Research; Oxidative stress; Polysaccharides; Psychological aspects; Quality of life; Rodents; China; diabetic; SOD; Astragalus polysaccharides; MDA; memory impairment
• ISSN: 1176-6328; 1178-2021; 1178-2021
• DOI: 10.2147/NDT.S106123

Astragalus polysaccharides (APS) are active constituents of Astragalus membranaceus. In this study, we aimed to investigate the effects of APS on memory impairment in a diabetic rat model and their mechanisms.
A diabetic model was established in 50 male Wistar rats with streptozotocin intra-peritoneal injection. A blood glucose level higher than 16.7 mmol/L obtained 72 hours after the injection was regarded as a successful diabetic model. The modeled rats were divided into model group, high, medium, and low doses of APS, and piracetam groups (positive control). A group of ten rats without streptozotocin-induced diabetes were used as a normal control. After respective consecutive 8-week treatments, the levels of blood fasting plasma glucose, insulin, hemoglobin A1c, memory performance, hippocampal malondialdehyde, and superoxide dismutase were determined.
After the 8-week APS treatment, serum fasting plasma glucose, hemoglobin A1c, and insulin levels were decreased compared with those of the model group (P<0.05). Importantly, memory impairment in the diabetic model was reversed by APS treatments. In addition, hippocampal malondialdehyde concentration was lowered, whereas that of superoxide dismutase was higher after APS treatments.
APS are important active components responsible for memory improvement in rats with streptozotocin-induced diabetes. The potential mechanism of action is associated with the effects of APS on glucose and lipid metabolism, and antioxidative and insulin resistance. APS are constituents of A. membranaceus that are potential candidate therapeutic agents for the treatment of memory deficit in diabetes.