Association between serum adropin level and burden of coronary artery disease in patients with non-ST elevation myocardial infarction

• Published in: Anatolian journal of cardiology Vol. 17; no. 2; pp. 119 - 124
• Main Authors: Ertem, Ahmet Göktuğ, Ünal, Sefa, Efe, Tolga Han, Açar, Burak, Yayla, Çağrı, Kuyumcu, Mevlüt Serdar, Kırbaş, Özgür, Köseoğlu, Cemal, Akboğa, Mehmet Kadri, Gayretli Yayla, Kadriye, Gökaslan, Serkan, Aydoğdu, Sinan
• Format: Journal Article
• Language: English
• Published: Turkey Kare Publishing 01-02-2017
• Subjects: Original Investigation
• ISSN: 2149-2263; 2149-2271
• DOI: 10.14744/AnatolJCardiol.2016.7149

Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relationship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI.
A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test.
Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998-1.000; p=0.007).
Adropin could be an alternative blood sample value for predicting severity of CAD.