A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster

• Published in: Genetics (Austin) Vol. 114; no. 1; pp. 111 - 123
• Main Authors: Cavener, D.R, Otteson, D.C, Kaufman, T.C
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Genetics Soc America 01-09-1986; Genetics Society of America
• Subjects: Animals; Biological and medical sciences; CHROMOSOME; Chromosome Mapping; CHROMOSOME NUMBER; CHROMOSOMES; Classical genetics, quantitative genetics, hybrids; CROMOSOMAS; DROSOPHILA; Drosophila melanogaster; Drosophila melanogaster - anatomy & histology; Drosophila melanogaster - genetics; Drosophila melanogaster - ultrastructure; Drosophilidae; Fundamental and applied biological sciences. Psychology; GENE; GENES; Genes, Lethal; Genetic Complementation Test; Genetics of eukaryotes. Biological and molecular evolution; GLUCOSA; GLUCOSE; Invertebrata; Investigations; Microscopy, Electron, Scanning; MUTACION; MUTATION; NOMBRE CHROMOSOMIQUE; NUMERO DE CROMOSOMAS; OXIDOREDUCTASES; OXIDORREDUCTASAS; OXYDOREDUCTASE; Phenotype; POLYTENY; Genetic mapping; Arthropoda; Insecta; Mutation; Invertebrata; Drosophila melanogaster; Diptera
• ISSN: 0016-6731; 1943-2631; 1943-2631
• DOI: 10.1093/genetics/114.1.111

A reanalysis of the 84B3 to 84D3,5 region of the polytene chromosomes of Drosophila melanogaster has led to the identification and localization of 16 genes. These genes include 11 vital loci, four genes exhibiting nonlethal visible mutant phenotypes and one gene encoding a nonessential enzyme. The identity of the gene products of two of the vital genes has been determined to be alpha-tubulin and glucose dehydrogenase (Gld). Three newly identified genes, sticking (stk), half out (hat) and trapped (ted), as well as Gld are required for eclosion. Among the nonessential genes are roughened eye (roe) and ruffed eye (rue), which affect eye texture. The roe phenotype is greatly enhanced by deletions that simultaneously remove roe and an unidentified locus in 84E. Mutations in another nonessential gene, rotund (rn), are characterized by pattern deletions of most adult appendages.