A randomized comparison of nifedipine and ritodrine for suppression of preterm labor

• Published in: European journal of obstetrics & gynecology and reproductive biology Vol. 77; no. 2; pp. 171 - 176
• Main Authors: Koks, Carolien A.M, Brölmann, Hans A.M, de Kleine, Martin J.K, Manger, Petra A
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01-04-1998; Elsevier
• Subjects: Adult; Betaadrenergic receptor agonists; Biological and medical sciences; Blood Glucose - metabolism; Blood Pressure - drug effects; Calcium channel blockers; Female; Genital system. Reproduction; Gestational Age; Humans; Medical sciences; Nifedipine - adverse effects; Nifedipine - therapeutic use; Obstetric Labor, Premature - prevention & control; Pharmacology. Drug treatments; Potassium - blood; Pregnancy; Pregnancy Outcome; Pregnancy, Multiple; Preterm labor; Ritodrine - adverse effects; Ritodrine - therapeutic use; Tocolytic Agents - adverse effects; Tocolytic Agents - therapeutic use; Twins; Preterm labor; Betaadrenergic receptor agonists; Calcium channel blockers; Human; Agonist; Pregnancy disorders; Calcium antagonist; β2-Adrenergic receptor; Tocolytic; Nifedipine; Chemotherapy; Randomization; Treatment; Female; Dihydropyridine derivatives; Threatened premature delivery; Ritodrine; Comparative study
• ISSN: 0301-2115; 1872-7654
• DOI: 10.1016/S0301-2115(97)00255-8

Objectives. To compare the efficacy and safety of nifedipine and ritodrine in preventing preterm labor, and to evaluate maternal side effects and neonatal outcome.
Study design. Non-blind, randomized controlled trial
Results. A randomized trial of 102 pregnant women with gestational ages under 34
weeks, including 24 with twin pregnancies and 45 on betasympathicomimetic drugs, who had regular uterine contractions with either observed cervical changes or preterm rupture of membranes. After stratification women were randomly assigned to receive either ritodrine intravenously or nifedipine orally. Fifty-five women were randomized to the nifedipine group and 47 to the ritodrine group. As expected, both groups were comparable in terms of several entry variables, including mean gestational age, ruptured membranes, treatment with tocolytic drugs, cervical examination, contraction frequency, age, and twin gestation. Delivery of women in the nifedipine group was delayed for 48
h, 7
days, and until 34
weeks gestation in 33 (60%), 26 (47%) and 21(38%) cases, respectively, compared with 31 (66%), 21(45%) and 11(23%) women in the ritodrine group (no significant difference). Maternal side effects were significantly less common in the nifedipine group than in the ritodrine group, however after 7
days of therapy there was no difference between the two groups. Neonatal outcome was similar in the two groups, with four neonatal deaths in the nifedipine and five in the ritodrine group.
Conclusions. Nifedipine seems to be as effective as ritodrine in the treatment of preterm labor and is associated with less frequent side effects.