Retromer-mediated endosomal protein sorting: all WASHed up

Highlights • Localised actin patches on endosomes define discrete domains to facilitate protein sorting. • Formation of branched actin on endosomes requires the WASH complex. • The retromer complex recruits the WASH complex to endosomes. • The WASH complex along with retromer sorts endosomal membran...

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Bibliographic Details
Published in:	Trends in cell biology Vol. 23; no. 11; pp. 522 - 528
Main Authors:	Seaman, Matthew N.J, Gautreau, Alexis, Billadeau, Daniel D
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-11-2013
Subjects:	actin Actins - metabolism Animals endosome Endosomes - metabolism Fam21 Humans Microfilament Proteins - metabolism Pathology Polymerization Protein Transport retromer sorting Vesicular Transport Proteins - metabolism WASH complex Fam21 endosome actin WASH complex retromer sorting
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Summary:	Highlights • Localised actin patches on endosomes define discrete domains to facilitate protein sorting. • Formation of branched actin on endosomes requires the WASH complex. • The retromer complex recruits the WASH complex to endosomes. • The WASH complex along with retromer sorts endosomal membrane proteins to multiple destinations.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2013.04.010