Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system

• Published in: Seminars in immunology Vol. 20; no. 4; pp. 228 - 235
• Main Authors: Laslo, Peter, Pongubala, Jagan M.R, Lancki, David W, Singh, Harinder
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-08-2008
• Subjects: Allergy and Immunology; Animals; B and T lymphocytes; Cell Differentiation - immunology; Cell fate determination; Cell Lineage - immunology; Gene Expression Regulation - immunology; Gene Regulatory Networks - immunology; Hematopoiesis - immunology; Hematopoietic Stem Cells - classification; Hematopoietic Stem Cells - cytology; Hematopoietic Stem Cells - immunology; Humans; Immune System; Lineage restriction; Lymphocytes - immunology; Macrophages; Myeloid and lymphoid lineages; Myeloid Cells - immunology; Neutrophils; Transcription factor antagonism; Myeloid and lymphoid lineages; Neutrophils; Lineage restriction; Transcription factor antagonism; Cell fate determination; Macrophages; B and T lymphocytes
• ISSN: 1044-5323; 1096-3618
• DOI: 10.1016/j.smim.2008.08.003

Abstract Considerable progress is being achieved in the analysis of gene regulatory networks that direct cell fate decisions within the hematopoietic system. In addition to transcription factors that are pivotal for cell fate specification and commitment, recent evidence suggests the involvement of microRNAs. In this review we attempt to integrate these two types of regulatory components into circuits that dictate cell fate choices leading to the generation of innate as well as adaptive immune cells. The developmental circuits are placed in the context of a revised scheme for hematopoiesis that suggests that both the innate (myeloid) and adaptive (lymphoid) lineages of the immune system arise from a common progenitor.