Analysis of ultrastructural glomerular basement membrane lesions and podocytes associated with proteinuria and sclerosis in Osborne-Mendel rats with progressive glomerulonephropathy

• Published in: Journal of veterinary science (Suwŏn-si, Korea) Vol. 14; no. 2; pp. 223 - 226
• Main Authors: Yasuno, K., Azabu University, Japan, Kamiie, J., Azabu University, Japan, Shirota, K., Azabu University, Japan
• Format: Journal Article
• Language: English
• Published: Korea (South) 대한수의학회 2013; The Korean Society of Veterinary Science
• Subjects: Animals; Animals, Outbred Strains; glomerular basement membrabne, kidney glomerules; Glomerular Basement Membrane - pathology; Glomerular Basement Membrane - ultrastructure; Kidney Diseases - complications; Kidney Diseases - etiology; Kidney Diseases - pathology; Male; Microscopy, Electron, Transmission; Nephrosclerosis - etiology; Nephrosclerosis - pathology; Nephrosis - complications; Nephrosis - pathology; Podocytes - pathology; Podocytes - ultrastructure; PROTEINURIA; Proteinuria - etiology; Proteinuria - pathology; PROTEINURIE; RAT; RATA; RATS; Short Communication; 수의학; kidney glomerulus; glomerular basement membrane; rat; proteinuria; podocyte
• ISSN: 1229-845X; 1976-555X
• DOI: 10.4142/jvs.2013.14.2.223

The renal glomeruli of 12 male Osborne-Mendel rats 3 to 24 weeks old were examined by electron microscopy. Effacement of podocyte foot processes developed at 3 weeks of age and became progressively worse over time. Loss or dislocation of the slit membrane was also found. Vacuoles and osmiophilic lysosomes appeared in the podocytes starting at 6 weeks of age.