Lymphoid Malignancies in U.S. Asians: Incidence Rate Differences by Birthplace and Acculturation

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 20; no. 6; pp. 1064 - 1077
• Main Authors: CLARKE, Christina A, GLASER, Sally L, GOMEZ, Scarlett L, WANG, Sophia S, KEEGAN, Theresa H, JUAN YANG, CHANG, Ellen T
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01-06-2011
• Subjects: Acculturation; Adolescent; Adult; Aged; Asian - statistics & numerical data; Biological and medical sciences; Child; Child, Preschool; Ethnicity; Female; Hematologic and hematopoietic diseases; Humans; Incidence; Infant; Infant, Newborn; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma - epidemiology; Lymphoma - etiology; Male; Medical sciences; Middle Aged; Registries; Residence Characteristics; Social Class; Tumors; United States; Young Adult; United States; North America; America; Human; Birth place; Acculturation; Asiatic; Cancerology; Lymphoproliferative syndrome; Malignant hemopathy; Epidemiology; Public health; Ethnic group; Cancer; Incidence
• ISSN: 1055-9965; 1538-7755; 1538-7755
• DOI: 10.1158/1055-9965.epi-11-0038

Malignancies of the lymphoid cells, including non-Hodgkin lymphomas (NHL), HL, and multiple myeloma, occur at much lower rates in Asians than other racial/ethnic groups in the United States. It remains unclear whether these deficits are explained by genetic or environmental factors. To better understand environmental contributions, we examined incidence patterns of lymphoid malignancies among populations characterized by ethnicity, birthplace, and residential neighborhood socioeconomic status (SES) and ethnic enclave status.
We obtained data about all Asian patients diagnosed with lymphoid malignancies between 1988 and 2004 from the California Cancer Registry and neighborhood characteristics from U.S. Census data.
Although incidence rates of most lymphoid malignancies were lower among Asian than white populations, only follicular lymphoma (FL), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), and nodular sclerosis (NS) HL rates were statistically significantly lower among foreign-born than U.S.-born Asians with incidence rate ratios ranging from 0.34 to 0.87. Rates of CLL/SLL and NS HL were also lower among Asian women living in ethnic enclaves or lower SES neighborhoods than those living elsewhere.
These observations support strong roles of environmental factors in the causation of FL, CLL/SLL, and NS HL.
Studying specific lymphoid malignancies in U.S. Asians may provide valuable insight toward understanding their environmental causes.