The K65R Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Exhibits Bidirectional Phenotypic Antagonism with Thymidine Analog Mutations

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Bibliographic Details
Published in:	Journal of Virology Vol. 80; no. 10; pp. 4971 - 4977
Main Authors:	PARIKH, Urvi M, BACHELER, Lee, KOONTZ, Dianna, MELLORS, John W
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for Microbiology 01-05-2006
Subjects:	Adenine - analogs & derivatives Adenine - pharmacology Amino Acid Substitution - genetics Anti-HIV Agents - pharmacology Arginine - genetics Biological and medical sciences Didanosine - pharmacology Dideoxynucleosides - pharmacology Drug Resistance, Multiple, Viral - genetics Fundamental and applied biological sciences. Psychology Genotype HIV Reverse Transcriptase - antagonists & inhibitors HIV Reverse Transcriptase - genetics HIV Reverse Transcriptase - physiology HIV-1 - drug effects HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Lysine - genetics Medical sciences Microbiology Miscellaneous Organophosphonates - pharmacology Phenotype Point Mutation Reverse Transcriptase Inhibitors - pharmacology Tenofovir Thymidine - analogs & derivatives Thymidine - genetics Vaccines and Antiviral Agents Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology Zalcitabine - pharmacology Zidovudine - pharmacology Immunopathology RNA-directed DNA polymerase Microbiology HIV-1 virus Enzyme Transferases Retroviridae AIDS Thymidine Immune deficiency Lentivirus Virology Infection Virus Nucleotidyltransferases Viral disease Human immunodeficiency virus Mutation
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Summary:	Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology. For an alternate route to JVI .asm.org, visit: JVI
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Corresponding author. Mailing address: University of Pittsburgh School of Medicine, Scaife Hall, Suite 818, 3550 Terrace Street, Pittsburgh, PA 15261. Phone: (412) 624-8512. Fax: (412) 383-7982. E-mail: Mellors@dom.pitt.edu.
ISSN:	0022-538X 1098-5514
DOI:	10.1128/JVI.80.10.4971-4977.2006