Epidemiological transition of colorectal cancer in developing countries: Environmental factors, molecular pathways, and opportunities for prevention

Colorectal cancer(CRC)is one of the leading causes of cancer and cancer-related mortality worldwide.The disease has been traditionally a major health problem in industrial countries,however the CRC rates are increasing in the developing countries that are undergoing economic growth.Several environme...

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Published in:	World journal of gastroenterology : WJG Vol. 20; no. 20; pp. 6055 - 6072
Main Authors:	Bishehsari, Faraz, Mahdavinia, Mahboobeh, Vacca, Michele, Malekzadeh, Reza, Mariani-Costantini, Renato
Format:	Journal Article
Language:	English
Published:	United States Baishideng Publishing Group Inc 28-05-2014
Subjects:	cancer Colorectal Colorectal Neoplasms - epidemiology Colorectal Neoplasms - prevention & control Colorectal Neoplasms - therapy countries Developing Developing Countries Diet Environment Epigenesis, Genetic Feeding Behavior Global Health Humans Intestines - microbiology Life Style Microbiota Obesity - complications Phenotype Receptors, Cytoplasmic and Nuclear - metabolism Risk Factors Topic Highlight Gut microbiota Developing countries Environment Diet Nuclear receptors Colorectal cancer
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Summary:	Colorectal cancer(CRC)is one of the leading causes of cancer and cancer-related mortality worldwide.The disease has been traditionally a major health problem in industrial countries,however the CRC rates are increasing in the developing countries that are undergoing economic growth.Several environmental risk factors,mainly changes in diet and life style,have been suggested to underlie the rise of CRC in these populations.Diet and lifestyle impinge on nuclear receptors,on the intestinal microbiota and on crucial molecular pathways that are implicated in intestinal carcinogenesis.In this respect,the epidemiological transition in several regions of the world offers a unique opportunity to better understand CRC carcinogenesis by studying the disease phenotypes and their environmental and molecular associations in different populations.The data from these studies may have important implications for the global prevention and treatment of CRC.
Bibliography:	Faraz Bishehsari;Mahboobeh Mahdavinia;Michele Vacca;Reza Malekzadeh;Renato Mariani-Costantini;Division of Gastroenterology, Robert H Lurie Comprehensive Cancer Center, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States;Division of Allergy-Immunology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, United States;Medical Research Council-Human Nutrition Research, MRC-HNR, Cambridge CB1 9NL, United Kingdom;Institute of the Metabolic Science IMS, Cambridge CB2 0QQ, United Kingdom;Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Shariati Hospital, Tehran 1411713135, Iran;Unit of General Pathology, Aging Research Center, G. d’Annunzio University Foundation, 66100 Chieti, Italy;Department of Medical, Oral and Biotechnological Sciences, G. d’Annunzio University, 66100 Chieti, Italy Author contributions: Bishehsari F designed the outline, searched and reviewed the literature, and prepared the manuscript; Mahdavinia M and Vacca M helped in conducting the search and drafting the manuscript; Malekzadeh R reviewed and edited the final draft; Mariani-Costantini R reviewed, and revised the final draft. Correspondence to: Faraz Bishehsari, MD, PhD, Division of Gastroenterology, Robert H Lurie Comprehensive Cancer Center, Northwestern University, 303 E Superior Street, Lurie 3-250, Chicago, IL 60611, United States. faraz-bishehsari@fsm.northwestern.edu Telephone: +1-312-5031837 Fax: +1-312-5032576
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v20.i20.6055