Impairment of Postural Control in Rabbits With Extensive Spinal Lesions

• Published in: Journal of neurophysiology Vol. 101; no. 4; pp. 1932 - 1940
• Main Authors: Lyalka, V. F, Orlovsky, G. N, Deliagina, T. G
• Format: Journal Article
• Language: English
• Published: United States Am Phys Soc 01-04-2009; American Physiological Society
• Subjects: Animals; Biomechanical Phenomena; Disease Models, Animal; Electromyography - methods; Functional Laterality - physiology; Hindlimb - physiopathology; Male; Medicin och hälsovetenskap; Movement - physiology; Postural Balance - physiology; Rabbits; Reflex - physiology; Sensation Disorders - etiology; Sensation Disorders - pathology; Spinal Cord Injuries - complications; Thoracic Vertebrae
• ISSN: 0022-3077; 1522-1598
• DOI: 10.1152/jn.00009.2008

Department of Neuroscience, Karolinska Institute, SE-17177, Stockholm, Sweden
Submitted 27 June 2008;
accepted in final form 15 January 2009
Our previous studies on rabbits demonstrated that the ventral spinal pathways are of primary importance for postural control in the hindquarters. After ventral hemisection, postural control did not recover, whereas after dorsal or lateral hemisection it did. The aim of this study was to examine postural capacity of rabbits after more extensive lesion (3/4 section of the spinal cord at T 12 level), that is, with only one ventral quadrant spared (VQ animals). They were tested before (control) and after lesion on the platform periodically tilted in the frontal plane. In control animals, tilts of the platform regularly elicited coordinated electromyographic (EMG) responses in the hindlimbs, which resulted in generation of postural corrections and in maintenance of balance. In VQ rabbits, the EMG responses appeared only in a part of tilt cycles, and they could be either correctly or incorrectly phased in relation to tilts. Because of a reduced value and incorrect phasing of EMG responses on both sides, this muscle activity did not cause postural corrective movements in the majority of rabbits, and the body swayed together with the platform. In these rabbits, the ability to perform postural corrections did not recover during the whole period of observation ( 30 days). Low probability of correct EMG responses to tilts in most rabbits as well as an appearance of incorrect responses to tilts suggest that the spinal reflex chains, necessary for postural control, have not been specifically selected by a reduced supraspinal drive transmitted via a single ventral quadrant.
Address for reprint requests and other correspondence: T. G. Deliagina, Dept. of Neuroscience, Karolinska Institute, SE-17177, Stockholm, Sweden (E-mail: Tatiana.Deliagina{at}ki.se )